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Our meta-evaluation confirmed a larger response rate with SAMe compared with placebo, with a global impact dimension starting from 17{faa39fcb9e8350a8d276972480ca6c1469006c0c9c2ab48bb76cf17dbd389b33} to 38{faa39fcb9e8350a8d276972480ca6c1469006c0c9c2ab48bb76cf17dbd389b33} depending on the definition of …